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@oxfordpdcentre -- home research our team giving videos publications seminars/events join us get involved news contact about us the oxford parkinson's disease centre (opdc) is a unique multidisciplinary research centre at the university of oxford supported by parkinson’s uk with funds from the monument trust, one of the sainsbury family charitable trusts. established in february 2010, the oxford parkinson’s disease centre (opdc) brings together internationally-renowned scientists who work on the genetics of parkinson’s, the generation of cell and animal models, and the wiring of brain circuits which control movement, with clinical experts in the diagnosis and treatment of parkinson’s. our world-class research centre was formed to understand the earliest events in the development of parkinson’s and create animal models with greater relevance to the disease, ultimately with a view to identifying the changes which occur before the symptoms become apparent. our programme targets the molecular pathways to parkinson’s in order to: understand the progression of parkinson’s predict the onset of parkinson’s identify potential drug targets for parkinson’s develop new treatments that will prevent the development of parkinson’s in at-risk individuals. watch the video below to learn more about opdc's research selected publications rolinski m , griffanti l , piccini p, roussakis aa, szewczyk-krolikowski k, menke ra , quinnell t, zaiwalla z, klein jc, mackay ce, hu mt. (2016) basal ganglia dysfunction in idiopathic rem sleep behaviour disorder parallels that in early parkinson's disease. brain . pmid: 27297241 baig f, lawton ma, rolinski m, ruffmann c, klein jc, nithi k, okai d, ben-shlomo y, hu mtm. (2017) personality and addictive behaviours in early parkinson’s disease and rem sleep behavior disorder . park rel dis . 37:72-78. pmid:28173973 sandor c, robertson p, lang c, heger a, booth h, vowles j , witty l, bowden r, hu m, cowley sa, wade-martins r, webber c. (2017) transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for parkinson's disease. hum mol genet. 26(3):552-566. pmid: 28096185 dodson pd, dreyer jk, jennings ka, syed ec , wade-martins r, cragg sj, bolam jp, magill pj (2016) representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. pnas , 113(15):e2180-8. pmid: 27001837. sloan m, alegre-abarrategui j, potgieter d, kaufmann ak, exley r, deltheil t, threlfell s, connor-robson n, brimblecombe k, wallings r, cioroch m, bannerman dm, bolam jp, magill pj, cragg sj, dodson pd, wade-martins r (2016). lrrk2 bac transgenic rats develop progressive, l-dopa-responsive motor impairment, and deficits in dopamine circuit function. human molecular genetics . 25(5):951-63. pmid: 26744332 news multi-year collaboration to advance the development of deubiquitinating enzyme (dub) inhibitors for the treatment of neurodegenerative diseases posted 10/05/2018 forma therapeutics, the opdc, and the alzheimer’s research uk oxford drug discovery institute (oddi) at oxford university announced today they have entered into a collaboration and license agreement to identify, validate and develop deubiquitinating enzyme (dub) inhibitors for the treatment of neurodegenerative diseases. dubs are a family of over a hundred proteases that play important roles in protein and cellular homeostasis, processes that ... congratulations to sally bromley, chair of parkinson's uk oxford on her honorary degree from all at opdc external link found on http://opdc.medsci.ox.ac.uk/news jonathan's big beautiful wall walk posted 09/05/2018 jonathan bromley, member of the oxford branch of parkinson's uk will be walking the length of hadrians wall over 5 days in june to raise money for parkinson's uk. jonathan's wife sally (chair of oxford parkinson's uk) was diagnosed with parkinson's in 2008. since then she has thrown herself wholeheartedly into fundraising and parkinson's support work, and jonathan thought it was about time he made a contribution too. i'm not roughing it ... click here to sign up to the opdc news mailing list seminars/events hélène plun-favreau - 13 june 2018 posted 21/03/2018 mitophagy modulation as a potential therapeutic target for neurodegenerative diseases ucl institute of neurology in recent years, it has become clear that even in clinically distinct neurodegenerative conditions, there are common underlying themes in how the neurons become sick and die. one such theme is a breakdown in the maintenance of mitochondria, which plays a central role in parkinson’s disease and in other neurodegenerative ... oxford dementia research day, thursday 12th july 2018 posted 08/06/2018 t he annual oxford dementia research day at st john's college oxford is jointly organised by nihr oxford health biomedical research centre and alzheimer's research uk oxford local network . this free meeting will include a full day of talks covering subjects including cellular and clinical research, managing dementia and cognition. there will also be poster sessions through the day with plenty of time for networking and an evening reception. click for details including how to register watch videos from open days and more at our youtube channel. find us on facebook tweets by oxfordpdcentre © 2018 oxford parkinson's disease centre, department of physiology, anatomy and genetics, le gros clark building, south parks road, oxford, ox1 3qx tel: 01865 282358 | enquiries: [email protected] driven by newt , powered by pinfox home | site map | contact | freedom of information | privacy policy | copyright | accessibility | medical sciences division | oxford university

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